Exudative erythema multiforme can be treated with topical medication, oral medication, as well as general measures to regulate. 1. Topical medication: when exudative erythema multiforme breaks out, patients need to apply local antibiotic ointment, such as erythromycin ointment, mupirocin ointment and so on according to doctor’s instruction. If there is no localized erosion, glucocorticoid ointment, such as dexamethasone ointment, mometasone furoate cream, etc., can be applied to the affected area under the guidance of the doctor. 2. Oral medication: For patients with exudative erythema multiforme, oral antihistamines such as loratadine and cetirizine, as well as glucocorticosteroids such as dexamethasone and prednisone can be taken as prescribed by the doctor. For patients with herpes simplex virus infection, they can use antiviral drugs such as acyclovir and famciclovir as prescribed by the doctor, while avoiding the use of glucocorticosteroids. 3. General measures: patients usually need to keep the lesion skin clean, local itching to avoid scratching. When you go out, you need to apply sunscreen or wear sunscreen clothing. It is suggested that patients with exudative erythema multiforme need to consult a doctor in time, and can choose appropriate measures for treatment under the doctor’s guidance.