Under normal circumstances, the range of total bile acid is 0-9.67μmol/L. If the test result is 16μmol/L, it is a high condition, which may be related to the following situations: 1. Physiological factors: A slight increase in total bile acid may be related to physiological factors, which is commonly seen as a transient increase in total bile acid after eating, which can return to normal after a period of time, so there is no need to worry. In addition, it may also be related to strenuous exercise, excessive fatigue, heavy drinking, etc. Patients should pay attention to regular life, properly relieve fatigue, and control the amount of alcohol consumption; 2, pathological factors: common in liver diseases, such as viral hepatitis, cirrhosis, fatty liver, liver cancer, etc.. The more severe the liver function damage, the more obvious the elevation of total serum bile acids. If the total bile acid is 16 μmol/L, there may be slight liver damage. In addition, diseases such as cholestasis, chronic renal insufficiency, impaired intestinal reabsorption of bile acids, and hyperthyroidism may cause an increase in total bile acids. Total bile acids are more sensitive to confirm the diagnosis of hepatobiliary diseases, and if a patient has a total bile acid of 16 μmol/L, relevant tests should be performed. For example, in toxic hepatitis caused by long-term use of isoniazid or phenytoin sodium, there will be an increase in total serum bile acid level even if there are no symptoms in the early stage. Therefore, a total bile acid of 16 μmol/L should be taken seriously, and the cause should be clarified and treated as early as possible.