Hoarseness in late stage of pancreatic cancer may be caused by the metastasis of pancreatic cancer compressing the recurrent laryngeal nerve, or it may be caused by other reasons. In the late stage of pancreatic cancer, there will be metastasis of cancer foci, and the location of metastasis can be all over the body, if the metastasis is to the larynx, lungs, lymph nodes in the neck, etc., the hoarseness of voice will occur if the laryngeal recurrent nerve is compressed, and at this time, most of the patients will be treated with palliative treatment, which is mainly to alleviate the patient’s symptoms. There may also be other reasons, such as the combination of acute and chronic laryngitis can also appear hoarseness, active anti-infection treatment can be improved; primary laryngeal tumor compression to the recurrent laryngeal nerve can appear hoarseness, can be surgical combined with chemotherapy; may also be the laryngeal trauma and other injuries to the nerve caused by. It is suggested that patients should actively consult the doctor for treatment to avoid delaying the condition.