Diffuse thyroid lesions with compression symptoms or abnormal thyroid function need to be treated with surgery or medication under the guidance of a doctor; if there are no symptoms and the thyroid function is normal, there is no need for treatment, and regular checkups are sufficient. 1. For diffuse thyroid lesions, if there is progressive enlargement of the thyroid gland, and there are symptoms of compression that cause respiratory difficulties or if there is a suspicion of combined thyroid cancer, surgery can be considered. 2. If the diffuse thyroid lesion is not serious and there is no serious goiter, but the thyroid function suggests hyperthyroidism, medication (including methimazole and propylthiouracil, etc.) and iodine 131 treatment can be chosen. Hypothyroidism can be treated with levothyroxine sodium tablets. 3. If diffuse thyroid lesions are caused by Hashimoto’s thyroiditis, there are no obvious clinical symptoms and thyroid function is normal, then there is no need for special treatment, and the thyroid ultrasound and thyroid function should be regularly rechecked. In conclusion, there are many causes of diffuse thyroid lesions, and the treatment of diffuse thyroid lesions depends on the cause of the disease, the function of the thyroid gland, and the degree of goiter. It is recommended that an individualized treatment plan be formulated after the endocrinologist has completed the relevant examinations.