Levofloxacin is in conflict with alcohol, the use of Levofloxacin while drinking alcohol will aggravate the burden on the liver, increase the concentration of the drug in the blood, make the chances of adverse drug reactions higher, or affect the therapeutic effect. As alcohol contains a large amount of ethanol, ethanol is metabolized by the liver, which in turn increases the metabolic burden of the liver to a certain extent and may cause damage to it. In addition, patients who drink alcohol while taking levofloxacin, alcohol is an inhibitor of liver drug enzymes, which will increase the blood concentration and increase the chance of adverse drug reactions. Levofloxacin is a quinolone antibiotic, and common adverse reactions include gastrointestinal adverse reactions, such as causing nausea, vomiting, abdominal pain, and bloating, as well as central nervous system adverse reactions, such as convulsions. When using antibiotics, the appropriate blood concentration is necessary to achieve the best therapeutic effect. Drinking alcohol affects the blood concentration, which in turn affects the therapeutic effect, may prolong the course of treatment, increase the risk of side effects, and may also induce the production of drug-resistant bacteria. In conclusion, patients taking levofloxacin should not consume alcohol, as well as food made from alcohol. If any significant discomfort occurs, it is necessary to go to the hospital in time.