Calf muscle soreness after running needs to be treated according to the cause of the disease, generally can be taken to rest, elevate the affected limbs and other general treatment, physiotherapy, drug therapy and other methods. 1. Local lactic acid accumulation: For calf soreness caused by local lactic acid accumulation after running strenuous exercise, it is recommended to take rest in time, elevate the affected limbs, avoid local activities, and promote the absorption of metabolites, and most of the patients can get better after rest. 2. Muscle spasm: for the calf muscle tension and spasm caused by strenuous exercise, the treatment suggests that the patient rest, localized hot compresses and other physiotherapy, oral meloxicam and other non-steroidal anti-inflammatory drugs or topical Yunnan Baiyao spray if necessary. 3. Trauma: For over-exercise such as strenuous running and other soft tissue injuries to the calf muscles, patients may experience calf pain. For treatment, it is recommended that the affected limb should be braked, rested, cold compresses should be applied at an early stage, painkillers such as ibuprofen should be given when the pain is severe, and it is recommended that the injury should be dealt with in the hospital in time. 4. Fasciitis: For localized fasciitis caused by long-term strain, patients may have calf pain after running and other pulling. Treatment is recommended to rest, avoid strenuous activities, local physical therapy such as hot compresses, oral celecoxib or external diclofenac diethylamine emulsion anti-inflammatory pain treatment. If the soreness of the calf muscles after running is not relieved, or accompanied by other symptoms, you should go to the hospital in time to see a doctor, to identify the cause and give targeted treatment. The use of drugs need to follow the doctor’s advice.