Symptoms of advanced liver metastasis from pancreatic cancer may include those caused by liver metastasis, as well as symptoms of the pancreas itself. If there is liver metastasis, patients may develop jaundice, which may manifest as yellow sclera, yellow urine and yellow skin all over the body. Abnormal liver function metabolism, the liver is involved in sugar metabolism, lipid metabolism and protein metabolism, if liver metastasis causes abnormal sugar metabolism, patients may have symptoms of hypoglycemia. If it affects lipid metabolism there may be dyslipidemia, and if it affects protein synthesis and metabolism there may be hypoproteinemia and malnutrition manifestations. The liver is also the site of coagulation factor secretion and synthesis, and if liver metastases are more severe, it may lead to coagulation dysfunction. If there are more liver metastases, pain may occur in the whole liver area, and ascites and general edema may appear after protein reduction. After the abnormal coagulation function, it may often cause gastrointestinal bleeding. Because many estrogens may be inactivated on the liver, if there are more metastases in the liver, it will affect the inactivation of estrogens, and some male patients may also develop breast development. The pancreatic aspect is mainly painful and may also affect blood glucose metabolism.