Whether long-term statin therapy is needed for plaque in the neck is mainly based on the clinical situation of the patient. If there is plaque in the neck accompanied by atherosclerotic diseases, such as stroke, myocardial infarction, coronary heart disease, peripheral vascular disease, to carry out the secondary preventive treatment of statin, so long-term application of statins is required. If the patient does not have concomitant atherosclerotic disease but has more than 50% stenosis of plaque in the neck, long-term treatment with statins is also required. If there is plaque in the neck, but not more than 50%, and there is no concomitant atherosclerotic disease, it is important to combine other risk factors, such as the presence of hypertension, diabetes mellitus, high blood lipids, obesity, and cigarette smoking, as well as genetic history and age. If ≥3 risk factors, there is an indication for primary prevention with statin therapy.