What is the pathogenesis of type 1 diabetes

Type 1 diabetes is a type of disease in which there is an absolute deficiency of insulin secretion due to the destruction of pancreatic beta cells, mostly in adolescents, and the pathogenesis is related to genetics, autoimmunity, and possibly viral infection. In terms of genetics, it is detected that some people with diabetic parents may have type 1 diabetes, with expression of ALA antigens on chromosome 6. Antibodies to pancreatic islet cells, such as antibodies to glutamic acid decarboxylase and antibodies to pancreatic islet cells, which are detected in type 1 diabetes, suggest a relationship with autoimmune diseases to the presence of autoantibodies that cause the destruction of pancreatic islet cells. Viral infections, patients with type 1 diabetes may be related to viral infections, is due to the symptoms of viral infections before the onset of type 1 diabetes, as well as the increase in patients with type 1 diabetes during outbreaks of viral infections, such as measles, mumps virus, poliovirus, and coxsackie virus epidemics, a condition that indicates a possible relationship with viral infections.