Stomach distress after quadruple therapy application is usually caused by the side effects of antibiotics, which is usually a normal reaction to the use of drugs, but may also be caused by aggravation of stomach disorders. Quadruple therapy includes two antibiotics as well as proton pump inhibitors and gastric mucosal protectors. If the antibiotics taken include metronidazole or clindamycin, etc., they may irritate the gastric mucosa and easily cause symptoms of gastric distress. At this point, it is usually recommended to stop the medication and visit the hospital promptly so that the doctor can decide whether treatment is needed. If treatment needs to be continued, consider that due to the excessive irritation of drugs such as metronidazole and clindamycin, it is recommended that patients can communicate with their primary care physician to change their medications in moderation and choose antibiotics that are less irritating to the gastric mucosa, such as amoxicillin. You can also take the medication after meals, which will reduce damage to the gastric mucosa, or reduce the dose of the medication to help relieve the symptoms of gastric distress. If the gastric distress is still not relieved, you can also give symptomatic treatment with drugs that protect the gastric mucosa, commonly used drugs include bismuth potassium citrate, metsylline, etc., which can provide relief, or temporarily stop the quadruple therapy and continue to take it after the gastric mucosal damage has recovered. Patients need to abstain from smoking, alcohol, spicy, coffee, tea, greasy and cold foods during the medication period, avoid staying up late and ensure sufficient sleep to avoid aggravating the condition and making the treatment ineffective.