Hand, foot, and mouth disease in children is an acute infectious rash disease caused mainly by enterovirus infection. In general, the more common means of transmission is gastrointestinal transmission, and then is the respiratory droplet transmission, the most important of which is close contact transmission. General hand, foot and mouth disease common enterovirus coxsackievirus a16 and enterovirus 71, which causes severe hand, foot and mouth disease encephalitis caused by death is mainly caused by enterovirus 71. Hand, foot and mouth disease is mainly epidemic every year from May 1 and lasts until about November. It generally infects mainly infants and children under the age of five, especially children under the age of three, and the incidence is the highest. Generally speaking, the best way to prevent HFMD is to go to crowded places, such as large playgrounds, especially some indoor playgrounds, during the high season of HFMD epidemic, when the incidence rate is relatively high, such as children under three years old. Because there are many children with HFMD, if a child with HFMD plays with a toy and another child plays with it, cross infection can easily occur. Be sure to distinguish between mild HFMD and severe HFMD. Mild HFMD, like most common colds, can be cured in 3-5 days. Severe HFMD can cause death if it is complicated by HFMD encephalitis. The main manifestations of severe HFMD are recurrent high fever, poor mental health, drowsiness, easy startling and frequent limb tremors.