High-grade plasma ovarian cancer IVB can be treated by surgery, chemotherapy, radiotherapy and hormone therapy. 1. Surgery: patients with stage IV often undergo tumor subtraction, for those who are difficult to achieve satisfactory tumor subtraction, 2~4 times of neoadjuvant chemotherapy can be carried out first, and then adjuvant chemotherapy can be carried out after surgery. 2. Chemotherapy: as an important treatment means for ovarian cancer, commonly used chemotherapeutic drugs such as paclitaxel, docetaxel, carboplatin and so on. 3. Radiotherapy: ovarian cancer is not sensitive to radiotherapy, and it can only be used for patients with limited tumors, such as metastases in retroperitoneal or mediastinal lymph nodes, and at the same time, it is difficult to be operated and the effect of chemotherapy is not good. 4. Hormonal therapy: for patients who cannot tolerate chemotherapy or chemotherapy is ineffective, they can be treated with drugs such as tamoxifen and letrozole. Specific therapy is needed to combine the patient’s condition specific analysis, the above drugs need to be applied under the guidance of a doctor.