Chronic atrophic gastritis is difficult to be cured completely and can exist for a long time. Comprehensive treatment such as eradication of Helicobacter pylori can prevent gastric mucosal atrophy to a certain extent, and the gastric mucosal atrophy can be reversed in some patients, but some patients still have the possibility of cancer. 1. This disease is a kind of digestive system disease mainly caused by Helicobacter pylori infection, and the symptoms of the patients are more insidious, usually asymptomatic or only nausea, bloating, epigastric pain and other indigestion manifestations, but some patients still have a certain chance of causing cancer. Therefore, early, active and regular treatment is of great value to the regression of this disease. 2. The treatment of chronic atrophic gastritis mainly includes drug therapy and lifestyle intervention. (1) Pharmacological treatment mainly involves the selective use of drugs to promote gastric motility, protect gastric mucosa, and inhibit gastric acid secretion, such as domperidone tablets, aluminum thioglycollate suspension gel, and famotidine tablets, as prescribed by the doctor. Patients need to follow the doctor’s instructions to use medication, if discomfort occurs, need to consult a doctor in time. (2) Lifestyle intervention is mainly to avoid cold and spicy diet, avoid overeating and so on. (3) For moderate or severe chronic atrophic gastritis or those who are highly suspected of malignant changes, timely surgical resection is also needed when necessary. Chronic atrophic gastritis is a precancerous disease, and early detection and treatment can effectively control the disease process.