Blood creatinine 161μmol/L suggests that blood creatinine is elevated, which can be divided into physiological and pathological factors. Physiologic factors include strenuous exercise, consumption of large amounts of high-protein diet, etc., which do not need to do renal puncture. Pathologic factors include nephrotic syndrome, glomerulonephritis, etc., and renal puncture biopsy is feasible for those who meet the indications. Physiological: after strenuous exercise or consuming a large amount of high protein diet, the blood creatinine may rise transiently, after resting or controlling the diet, the blood creatinine can be restored to normal, so there is no need to do renal puncture. Pathologic: Including nephrotic syndrome, glomerulonephritis and other diseases, renal puncture biopsy is feasible for those who meet the indications. Clear indications for renal puncture include: primary nephrotic syndrome, rapidly progressive renal failure due to glomerulonephritis, unexplained glomerulonephritic proteinuria with abnormal urinary sediment or persistent proteinuria, identification of renal transplant rejection, cyclosporine toxicity, recurrence of pre-existing renal disease or new renal pathology, and unexplained decreased renal function. Whether the need for renal puncture should be determined by the clinician to rule out contraindications, combined with the patient’s own condition, if the patient is older, in poor general condition, with a variety of underlying diseases, generally not recommended to perform a renal puncture biopsy. If you suffer from kidney disease, it is recommended that you go to the hospital as soon as possible, and let the professional doctor decide whether or not to do renal puncture, and follow the doctor’s instructions to standardize the diagnosis and treatment.