Case: A colleague took a meal after taking medicine for a cold, drank some wine, and ended up feeling extremely unwell in the middle of the night, with chest tightness and shortness of breath, and was pulled by 120 to the hospital for a night, finally pulling him back from the arms of death, and this colleague talked about it and felt scared afterwards, and has since quit drinking completely. Strictly speaking, as long as the drug is taken, it is no longer appropriate to drink, whether it is red wine beer or liquor, as long as the drug is taken, it is not appropriate to drink within one to two days of stopping the drug. There are several categories of drugs that are particularly deadly to alcohol, and taking these types of drugs and then drinking alcohol will trigger a series of medical discomfort called disulfiram reactions, which can be life-threatening. What is a disulfiram reaction? The reaction caused by drinking alcohol after taking a drug is called a disulfiram reaction. Disulfiram itself is a drug for alcohol withdrawal, and when combined with ethanol, disulfiram can inhibit the enzyme acetaldehyde dehydrogenase in the liver, so that after the oxidation of ethanol to acetaldehyde in the body, it cannot continue to break down and oxidize, resulting in a series of reactions caused by the accumulation of acetaldehyde in the body. Disulfiram-like reactions – Many drugs have similar effects to disulfiram. If alcohol is consumed after the drug, facial flushing, conjunctival congestion, blurred vision, violent pulsation of the blood vessels in the head and neck or pulsating headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain, myocardial infarction, acute heart failure, difficulty with inspiration, acute liver injury. convulsions and death, etc. The first category: cephalosporin antibiotics including cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin (Pioneer V), cefaladin (Pioneer VI), cefmetazole, cefminox, laxative cephalosporin, cefmenoxime, cefamandole, cefadroxil (Pioneer IV), cefaclor, etc.), dysentery, chloramphenicol, furantoin, metronidazole, etc. The disulfiram-like reactions that can occur when alcoholic beverages are consumed after taking cephalosporins, with particular attention to cefoperazone, the drug most sensitive to alcohol. The severity of the disulfiram reaction is directly proportional to the dose of the applied drug and the amount of alcohol consumed, and the reaction is heavier when drinking liquor than beer and alcoholic beverages. People with underlying cardiovascular disease may be so severe as to cause whistling depression, heart failure or even death. The second category: sedative-hypnotic drugs such as phenobarbital, chloral hydrate, Valium, Librium, these brain depressants, under the action of ethanol, will be absorbed by the body to accelerate, but also slow down its metabolism, so that the concentration of drug components in the blood in a short period of time rapidly increased. After drinking alcohol, alcohol excites and then inhibits the central nervous system of the brain. Together with these brain depressants, the normal activities of the central nervous system are severely inhibited, which can lead to coma, shock, whistle failure and death. It is said that the comedian Chaplin died from taking sleeping pills after drinking. The third category: antipyretic analgesic class such as aspirin, paracetamol, etc.. These drugs themselves have a stimulating and damaging effect on the gastric mucosa, and alcohol also hurts the stomach, both of which can lead to gastritis, gastric ulcers, gastric bleeding, etc. There are many kinds of alcohol, but if you drink wine after taking such drugs, you will be prone to accidents. This is because wine contains tyramine, which, if accumulated in large quantities, can cause significant damage to the human body, resulting in dizziness and headache, nausea and vomiting, diarrhea, cardiac arrhythmia, increased blood pressure and even cerebral hemorrhage. When drinking normally, the tyramine can be destroyed by the body naturally, but if the body is unable to successfully destroy tyramine after taking such drugs, it is inevitable that something will happen, and the consequences will be quite serious. The fifth category: glucose-lowering drugs diabetics should also pay extra attention to the injection of insulin or oral hypoglycemic drugs, drinking alcohol on an empty stomach, it is easy to have a hypoglycemic reaction. It is worth being alert to the fact that such hypoglycemic symptoms manifest as panic, sweating, fatigue and weakness, and even irritability, confusion and multilingualism, which are often masked by drunken reactions and are not easily distinguished from drunkenness, so that even if severe and persistent hypoglycemia occurs, and the patient is often oblivious to it, hypoglycemic shock eventually occurs. If not treated in time, it may lead to irreversible damage to brain tissue and even cause death.