Perianal eczema medications can be categorized into topical medications and systemic medications. Perianal eczema is due to a variety of factors stimulation, caused by the anal opening and the surrounding skin inflammatory reaction. 1. Topical medication: if there is exudation, you can use boric acid solution, glycerite lotion, with tretinoin solution, hydrocortisone ointment and other drugs, if there is a secondary bacterial infection, you can use erythromycin ointment, mupirocin ointment and other antibiotics. 2. Systemic medication: Oral chlorpheniramine maleate, ipecac, loratadine and other antihistamines to relieve itching. In addition to medication, perianal eczema should also pay attention to hygiene, develop good living habits, change the bad environment, avoid scratching and stimulation. Perianal eczema should be timely medical treatment, drugs need to be used under the guidance of a doctor.