The biggest difference between cold precipitation and plasma is that the concentration and activity of various clotting factors in cold precipitation is significantly higher than that of plasma, because plasma is the liquid part that remains after blood cells are separated from blood, which contains various clotting factors; whereas cold precipitation is the further processing of plasma to make the concentration of various clotting factors in it higher, so the activity and concentration of various clotting factors in cold precipitation is significantly higher than that of plasma. Therefore, the activity and concentration of various clotting factors in cold precipitation are significantly higher than those in plasma. Both cold precipitation and plasma are widely used in clinical practice, mainly in various coagulation disorders, such as hemophilia A and hemophilia B. Patients need to be transfused with plasma or cold precipitation to increase the activity of clotting factor VIII or clotting factor IX in the blood, which can significantly improve the patient’s bleeding symptoms. Also, for vitamin K deficiency, disseminated intravascular coagulation, and coagulation dysfunction caused by severe liver disease, cold precipitation or plasma transfusion can be used for treatment.