Pathologic grading of IgA nephropathy includes Lee classification, Oxford classification and so on, among which Lee classification is divided into 5 grades. Grade I: In this stage, the glomeruli are mostly normal, with occasional mild thylakoid widening (segmental) with or without cellular proliferation, while the tubules and interstitium are unchanged. Grade II: Patients in this stage have focal proliferation and sclerosis of the glomeruli (<50%), with rare small crescents, and no tubular or interstitial damage. Grade III: In this patient, the glomeruli show diffuse proliferation and widening of the thylakoid membranes (occasional focal segments), with occasional small crescents; tubular and interstitial changes show focal renal interstitial edema, occasional cellular infiltration, and rare tubular atrophy. Grade IV: Glomerular lesions show severe diffuse thylakoid hyperplasia and sclerosis, with partial or total glomerulosclerosis and visible crescents (<45%). Renal tubular atrophy, renal interstitial infiltration, occasional renal interstitial foam cells. Grade V: Glomerular lesions similar in nature to grade IV, but more severe, with glomerular crescent formation >45%; tubular and interstitial lesions similar to grade IV, but more severe. The M of Oxford classification refers to the degree of lesions of the mesangial cells, while E indicates the degree of lesions of the endothelial cells, S stands for segmental sclerosis or adhesions, etc., T indicates the condition of tubular atrophy or renal interstitial fibrosis, and C indicates cellular or cellular fibrous crescent. It is suggested that IgA Nephropathy patients should go to the hospital in time for consultation, clear grading under the guidance of professional physicians and timely treatment.