Fever in the toes may be caused by infectious diseases, abnormalities in the thermoregulatory center, rheumatic immune diseases and other factors. 1. Infectious diseases: Fever in the toes, which may mean fever in the toes, is mostly seen in infectious diseases, such as fungi, bacteria, viruses, mycoplasma, chlamydia, parasites and other local infections, which may cause localized redness, swelling, heat and pain, leading to fever in the toes. 2. Abnormalities of thermoregulatory center: Non-infectious factors, such as abnormalities of the thermoregulatory center, can affect the function of the thermoregulatory center, resulting in increased body temperature or localized fever. 3. Rheumatic immune diseases: Rheumatic immune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis, osteoarthritis, gouty arthritis, may also lead to redness, swelling and fever in the toes. In addition to this, autonomic dysfunction, endocrine or metabolic disorders, and absorption of aseptic necrotic substances may lead to fever in the toes. It is recommended to go to the general internal medicine department of the hospital to look for the cause and then give treatment for the cause.