There are still more reasons for the soreness of the thigh bone, there are several reasons: 1, it may be a benign local bone lesion, such as bone cyst, bone giant cell tumor, bone fibrous dysplasia, aneurysmal bone cyst, osteochondroma, etc. The pain level of these diseases is generally not very intense, sore or vague; 2, it may be a malignant bone lesion, such as osteosarcoma, Ewing sarcoma; 3, it may be chronic osteomyelitis, multiple myeloma, long-term running and jumping sports, etc. Patients can go to the hospital for a thigh x-ray to understand whether there are obvious lesions in the bones and, if necessary, combined with a thigh MRI to understand whether there are obvious abnormalities in the bone marrow cavity. If it is a benign skeletal lesion, it can be treated by local surgical scraping and bone grafting; if it is a malignant skeletal lesion, it requires extended surgical excision and amputation if necessary; if it belongs to chronic osteomyelitis, anti-inflammatory antibiotics such as levofloxacin should be given in time.