Itching in the thigh groove requires careful observation of skin changes in the itchy area. If the itchy area shows obvious erythema and papules, symmetrically distributed on both sides, consider the possibility of eczematous dermatitis formed by simple allergic and irritating factors. It is recommended to choose to use oral loratadine tablets with topical hydrocortisone butyrate cream for treatment. If the itchy area has obvious ring-shaped changes, with raised edges and depressions in the middle, it is considered to be ringworm caused by fungal infection, and it is recommended to use oral terbinafine hydrochloride tablets and topical miconazole nitrate ointment for comprehensive treatment. If the itchy area has obvious keratotic hyperplasia, it is considered to be keratotic dermatitis, and it is recommended to choose compound lactic acid cream or salicylic acid cream, which has a significant role in softening the skin.