As the use of desensitization therapy in children with allergic rhinitis is gradually increasing, the number of inquiries about desensitization therapy is also increasing, so here is a brief introduction for parents of affected children. Desensitization, also known as allergen-specific immunotherapy, is the only method known to alter the natural course of allergic disease. It was originally administered subcutaneously and has been used ever since, but in 1986 the British Pharmaceutical Society reported several deaths caused by subcutaneous injections and the search for an alternative began. In 2008, the official article of ARIA recommended sublingual desensitization as a treatment method for adults and children with allergic rhinitis, and it has also been used and studied in China. Numerous clinical studies have shown that desensitization therapy can change the natural course of allergic diseases and have a preventive effect on the further development of asthma. The sublingual method has a very good safety profile, with only some numbness and swelling of the lips and mouth, which will disappear quickly, and the rate of these adverse reactions decreases significantly if sublingual administration is replaced by spitting out afterwards. The minimum age for sublingual desensitization therapy is not conclusive, but general research suggests that it can be performed on anyone over 2 years of age who can cooperate with sublingual administration. According to the clinical data of our department in the past three years, there are two trends: first, the efficiency of controlling allergic asthma attacks is higher than that of allergic rhinitis and higher than that of allergic eczema, and second, the overall efficiency is 70-75%, but not every patient has an effect. In the past three years, there are patients who have finished the course of treatment and the effect is so satisfactory that they no longer need to take anti-allergy drugs and asthma treatment drugs. However, there are also ringtowns that have given up desensitization treatment because of unsatisfactory results or no results at all. There are a number of factors that affect the effectiveness of desensitization treatment. 1, the allergen must be identified and must be a single allergen for desensitization, and the higher the positive titer, the better the effect of desensitization. 2, the quality of desensitization drugs, the only one that has been listed and used clinically is Changdi, which is for mites and is not effective for others. 2, the doctor who performs desensitization must be a professional desensitizer with special training. The age of the child and the effect of the treatment also have a certain relationship. Children aged 2-4 years old have poor resistance, frequent colds and fevers, and coughs, resulting in frequent suspension of the use of desensitizing drugs, which has not been able to enter a good therapeutic concentration, and the desensitizing effect is not obvious. In older children, the therapeutic effect is easier to see, and compliance is good, so it is easy to stick to the course of treatment. The side effects of sublingual desensitization are mild, mainly numbness of the mouth and lips, swelling, rash, diarrhea, etc., and can be relieved and disappear on their own, but sometimes for extremely allergic children, it can cause allergic cough and asthma, which requires symptomatic treatment and attention.