Contraindications to eating ganoderma lucidum spore powder are mainly seen in the following cases: First, patients prone to allergies eat spore powder, there will be allergies to the skin or other organs, manifested as rashes, throat edema, etc. Secondly, patients with poor spleen and stomach function cannot eat it, because after taking spore powder orally, nausea, vomiting, diarrhea, and even dizziness and other symptoms will easily appear, which is fatal for patients with chronic diseases, such as suffering from hypertension after eating spore powder, which will further increase blood pressure and induce unpredictable diseases such as cerebrovascular accident, cerebellar hemorrhage, cerebral thrombosis, etc. Therefore, it should be used with caution or not in the clinic. Thirdly, it is not recommended to be applied to patients before and after surgery, because spore powder will have the condition of coagulation change, and its use before and after surgery as well as during surgery will lead to bleeding or other symptoms of patients.