Patient: At the very beginning of the illness, he was very weak, thought that others knew what he was thinking, had hallucinations of people targeting him and cursing him, and had the reaction of running away, but his thinking was always logical. Then he got better with treatment and had no hallucinations and was exactly like a normal person (supposedly cured). However, the first time I got better, I relapsed because I stopped taking the medication, and the second time I got better, I relapsed again because I was mentally overburdened. Now I am taking medication all the time, but I always have hallucinations of what I think and what other people know, my memory is not very good, and I have hallucinations of people cursing him when I get emotional. The rest of his body is normal, and he is currently working normally. It has been about 9 years since the onset of the disease. He has changed doctors and hospitals and medications during the course of his treatment, and now this doctor has only told him to do his best. However, we would like to know if it is possible to cure his “delusions” with the current medical technology. Is it really as uncertain as the doctor says? Also, do you think that the elimination of the “delusions” is an indication that the disease has been cured? Yang Mingzhe, psychiatrist, Guangzhou Brain Hospital: Generally speaking, the current drug treatment should not be a big problem for the symptoms, but because the cause and pathogenesis of the disease are not yet known, there is not much certainty that the disease can be cured, and most patients need to take medication for a long time, and some even need to take medication for life. Patient: Do you mean that the main purpose of taking medication is just to control your condition? Since there is no certainty of a cure, is it possible to eliminate the delusions in the mind through medication? As for long-term or even lifelong medication, will it have a greater impact on his health and fertility? Yang Mingzhe, Psychiatry Department, Guangzhou Brain Hospital: Theoretically, medication can treat any psychotic symptoms, including delusions, but 20-30% of patients are refractory to treatment, and the efficacy of medication is less than ideal. Long-term medication has certain side effects, but the physical condition will be reviewed regularly and the medication will be adjusted at any time, so the damage to the body should not be too great. Patient: I don’t know if his condition falls into that 20 – 30% refractory range. He is now working and living normally, fully cooperating with his medication, married, and able to communicate with people normally. He has been cured once or twice before. How sure do you think he will be cured again? The longer he takes the medication, the more stable his condition will be and the less chance of relapse.