Skin like fish scales generally refers to ichthyosis, which is a keratinization disorder characterized by dry skin with fish scale-like scales. The treatment of ichthyosis is mainly based on drug therapy, specific should follow the doctor’s instructions. Ichthyosis patients can follow the doctor’s instructions to use urea cream, lactic acid ointment, vitamin E cream, etc., can play a role in skin moisturizing, but also the use of retinoic acid topical preparation, calcipotriol ointment, etc., to improve the keratinization, reduce the scales have a certain effect, and glucocorticosteroids can be combined with glucocorticosteroids to increase the effectiveness of the drug. In addition, for patients with serious symptoms, oral isotretinoin and other drugs, for patients with bacterial infection also need oral erythromycin and other antibiotics for treatment. Ichthyosis patients should actively cooperate with the doctor’s treatment, not self-medication, so as not to delay the disease or skin adverse reactions. At the same time, daily should develop good habits, pay attention to skin moisturizing, use mild non-irritating soap bath, etc., can promote the recovery of the disease.