First of all Midodrine is an antihypertensive drug, which is mainly used for the treatment of postural hypotension. Midodrine is metabolized in the human body to produce active substances that activate alpha-adrenergic receptors on the arteries and veins, thereby causing vasoconstriction and raising blood pressure. At the same time, the metabolites of the drug do not cross the blood-brain barrier, so they do not affect the function of the nervous system, nor do they agitate the beta-adrenergic receptors on the heart and cause reflex heart rate increase. Midodrine is mainly used in the clinical treatment of postural hypotension. It can be taken orally if the postural hypotension does not improve and affects the patient’s life after lifestyle improvement and non-pharmacological treatment. In addition, Midodrine is also used for the treatment of female stress urinary incontinence.