The hepatitis B surface antigen value of more than 4000, this value is still relatively high, it is positive, reflecting the infection of hepatitis B virus, need to do further hepatitis B DNA and liver function to assess the condition. If the patient’s liver function is normal, simple hepatitis B surface antigen is positive, hepatitis B DNA is also positive, such patients are only hepatitis B carriers, generally do not need to do special treatment, regular review can be. If the patient’s liver function is abnormal and the hepatitis B DNA is also positive, antiviral treatment is required, and the antiviral needs to be taken for a long time. Sometimes monitoring changes in hepatitis B surface antigen values is also a way to monitor the effectiveness of antiviral therapy. The hepatitis B surface antigen value should be monitored dynamically every 3-6 months, and if the value is decreasing continuously, it indicates that the antiviral therapy is working well.