Whether lupus nephritis type 4 can have children needs to be decided by a doctor after a comprehensive evaluation. The evaluation criteria for men and women are different, but female patients may experience flare-ups or exacerbation of lupus during pregnancy. 1. For male patients with lupus nephritis type 4, the immunosuppressive drugs used in the treatment have little effect on the sexual function and semen quality of male patients. After stopping the immunosuppressive drugs for half a year, male patients can check the semen routine and quality and prepare for pregnancy. 2. For female lupus nephritis type 4 patients, pregnancy is a big burden to themselves, they need to stop using immunosuppressant drugs for more than half a year after their condition is stabilized before they prepare for pregnancy, and the hormone level may increase during pregnancy and the immune function may be abnormal. This may lead to lupus flare-ups or exacerbations, and requires close monitoring of kidney function and fetal development.