In myelofibrosis, splenomegaly is not a contraindication to bone marrow transplantation. In case of mild splenomegaly, it usually does not affect the bone marrow transplantation procedure, and in case of a huge spleen, it needs to be weighed by the doctor to see if it is possible to perform a bone marrow transplantation.
Myelofibrosis is a myeloproliferative disease in which bone marrow hematopoietic tissues are replaced by fibrous tissues, with varying degrees of bone marrow fibrous tissue proliferation. The spleen is often the main organ of extramedullary hematopoiesis in this disease, and splenomegaly is one of the common symptoms of this disease.
For the treatment of myelofibrosis, there is still a lack of effective measures, bone marrow transplantation is a promising treatment, so when conditions permit, you can choose to undergo bone marrow transplantation.
While splenomegaly is not a contraindication to bone marrow transplantation, if there is an indication for splenectomy, it is necessary to consider whether or not to perform splenectomy first, in order to ameliorate the situation of an enlarged spleen compressing the surrounding tissues, as well as splenic hyperfunction and so on.
Whether bone marrow transplantation is possible in myelofibrosis with splenomegaly needs to be determined after a comprehensive evaluation by the doctor, and it is recommended to cooperate with the doctor to receive appropriate treatment.