Rituximab treatment for membranous nephropathy needs to be used a few times need to be assessed according to the severity of the disease and personal constitution, there is a certain degree of variability, can not be generalized. If the patient’s condition is not particularly serious and the individual’s physical condition is relatively good, generally applying 1~2 courses of treatment, i.e. 4~8 times, may have a better therapeutic effect. If the patient’s condition is more serious or the individual’s physical condition is poorer, the time of using the medicine usually needs to be extended, and it may need about 2~3 courses of treatment, i.e., 8~12 times, or even the treatment time needs to be longer, or it may not be cured. It should be noted that rituximab is contraindicated for those who are allergic to the components of the drug, pregnant and breastfeeding women, acute stage of rheumatoid arthritis, and those with severe heart failure. It is also necessary to pay attention to the prevention of infections, especially the risk of serious infections. Patients with membranous nephropathy are advised to go to regular hospitals in time to give targeted treatment or therapy under the guidance of doctors, and do not self-medicate.