Possible reasons for waking up in the middle of the night with urine include chronic urinary retention, overactive bladder syndrome, psychological factors, and drinking too much water before bedtime. 1. Chronic urinary retention: Normally, the bladder is in a state of water storage, and the bladder will be emptied every time you urinate, but in some patients, the mechanism of emptying the bladder is affected, and the residual urine in the bladder is too much, and half of the bladder is always accumulated in the bladder, which makes it easy to produce obvious frequent urination. 2. Overactive bladder syndrome: the bladder often contracts involuntarily, and when it contracts, it wants to go to the toilet. It can be caused by a variety of factors, such as infections, tumors, and nerve injuries, which lead to unstable bladder function. 3. Psychological factors: some patients have bad urination habits, always feel urine in the bladder before lying down to sleep, and can only fall asleep after going to the toilet, which is caused by urination habits or psychological factors. 4. Drinking too much water before going to bed: If you drink too much water before going to bed, it may lead to waking up in the middle of the night to be held back by urine, pay attention to reduce the amount of water before going to bed will be relieved on its own. It is recommended that the patient consult a doctor in a timely manner to clarify the cause of the disease, and under the guidance of the doctor’s treatment.