Inert lymphomas progress slowly and early treatment follows palliative principles.
Small lymphocytic lymphoma, lymphoplasmacytic lymphoma, marginal zone lymphoma and follicular lymphoma are all B-cell inert lymphomas. Inert lymphoma progresses slowly, has a relatively long natural course, and is not easy to be relieved even though it has a certain effect on radiotherapy and other treatments.
For cases with no clinical symptoms at diagnosis and a small tumor load, it is appropriate to adopt a wait-and-see approach.
For advanced stages, for symptomatic patients with progressive stages (stage III or IV), aggressive comprehensive treatment should be used, including Ono radiation combined with chemotherapy and INF-α (interferon-α), and chemotherapy may be used as appropriate, with drugs including rituximab and ibrutinib.
Specific diagnosis and treatment need to be carried out under the guidance of a physician.