There are many kinds of sedative and sleeping drugs commonly used in clinical practice, the sedative and sleeping drugs with short half-life include zolpidem, dexrazoxane, etc. These sedative and sleeping drugs with short half-life are relatively effective mainly for patients who have difficulty in falling asleep. In addition, there are some medium-acting or long-acting half-life sedative sleeping drugs, relatively slow onset and longer maintenance time, common drugs are diazepam, eszopiclone, these medium- and long-acting drugs are generally recommended for patients who are prone to wake up in the middle of the night, easy to wake up early. Therefore, patients in different situations choose different sleeping drugs, mainly according to the symptoms to choose a more appropriate sedative sleeping drugs.