Diabetic nephropathy works with medicine. Diabetes causes kidney changes, it is a matter of time, 5 years, 10 years, or even 20 years later, as time goes by causing sugar kidney, the incidence is increasing, and the symptoms are getting worse. The occurrence of diabetic nephropathy is now thought to be closely related to blood sugar fluctuations. So for patients with diabetic nephropathy, the first thing is to control blood sugar, whether with drugs or diet control, must control blood sugar. And some glucose-lowering drugs such as gliquidone, SGLT-2 inhibitors, GLP-1 agonists and other drugs have the effect of reducing urinary protein and mitigating diabetic nephropathy while lowering glucose, which need to be selected in combination with the kidney function of patients. In addition, some drugs can be used to reduce urine protein and creatinine to slow down the progression of diabetic nephropathy.