The process of diabetic nephropathy can be divided into five stages, as follows: 1. Stage I kidney volume increases, glomerular filtration rate increases; 2. Stage II normal urinary albumin phase, through the examination of urinary albumin excretion rate found <20μg/min, or <30mg/24h, when urine routine testing found proteinuria is often negative, the beginning of minor glomerular damage; 3. Stage III for early diabetic nephropathy stage, at this time there is iconic, persistent microalbuminuria, albuminuria detection 20-200μg/min, or 30-300mg/24h, glomerular lesions are developing; 4, stage VI begins to enter the clinical diabetic nephropathy stage, began to appear a large amount of albuminuria, the amount of albuminuria per day can be > 300mg, urine routine detection can be found to be positive for urine protein, pathology The glomerular lesion is more serious and partial sclerosis begins to appear; 5. Stage V is the stage of renal failure, which will result in a significant increase in blood creatinine and complications of uremia.