Depakene is the trade name for sodium valproate extended-release tablets, which are mainly used in the clinical treatment of epilepsy. How long it takes for oral administration to work depends on the patient’s sensitivity to Depakene and the method of administration, which usually takes effect in a week to a month. Depakene is mainly used for generalized epilepsy and partial epilepsy, such as aphasic seizures, atonic seizures, tonic spastic seizures, partial seizures, etc. Oral administration will be divided into one to two daily doses, which can be changed to once a day for long-term oral administration after the epilepsy is effectively controlled, and the extended-release tablets should be swallowed whole and not bitten orally. The following conditions are not recommended for oral administration: patients with acute and chronic hepatitis, severe liver disease, or patients with a history of drug-related liver injury, etc. Depakene is also used for the treatment of mania, which will be well controlled after about one week of administration. After complete control of symptoms, the dose can be reduced and maintained according to blood levels and clinical symptoms for long-term oral use.