What are the effects of Depakene? Depakene is used as an antiepileptic drug for patients with persistent seizures, generalized seizures, or intractable seizures. The advantage of Depakene is that it is an extended-release tablet, which can maintain the blood concentration of the drug in a relatively stable state, and the number of times a day it can be taken once or twice a day is sufficient. It is also very widely used in neurological and psychological aspects. Generally Depakene is effective as a new stabilizer and is still very good to use.