Taking Irbesartan can not maintain 24-hour blood pressure reduction, you can increase the dose of the drug or replacement, combined with other antihypertensive drug treatment. Clinically, Irbesartan belongs to the angiotensin II receptor antagonist, mainly able to block the vasoconstriction effect of tissue angiotensin II receptor antagonist, so as to reduce blood pressure. If you can’t achieve the effect of lowering blood pressure in 24 hours after taking the drug, you can follow the doctor’s instructions to take the drug for a second time or increase the dosage of the drug. Secondly, you can combine with hydrochlorothiazide and other antihypertensive drugs for treatment, usually after the combination of drugs can reduce the extracellular volume, reduce peripheral vascular resistance, so as to play a joint effect of lowering blood pressure. Can also be replaced with long-acting antihypertensive drugs, such as calcium channel blockers in the amlodipine, after taking can prolong the effect of lowering blood pressure. Usually, Irbesartan may cause tinnitus, headache and other uncomfortable symptoms after taking it. Secondly, diabetes mellitus, patients with moderate to severe renal impairment are forbidden to use, while pregnant and lactating women, patients with renal vascular hypertension need to be used with caution. If after taking Irbesartan, the desired effect of lowering blood pressure is not achieved, it is recommended to consult a doctor in a timely manner, and adjust the medication after the doctor’s comprehensive assessment of the condition.