Thick and yellow nasal mucus is commonly seen in rhinitis combined with bacterial infection, sinusitis, nasal tumor, etc. It needs to be treated according to the specific cause after examination in the ENT department of the hospital, and general treatment, medication, surgery, etc. will be taken after clear diagnosis. 1. Rhinitis combined with bacterial infection: often manifested as thick yellow nasal mucus, nasal congestion, headache, etc., and in severe cases, it will cause fever and chills. Antibiotic medication can be prescribed, such as amoxicillin, cefixime, etc., with a history of drug allergy patients prohibited; at the same time with physiological sea saline nasal spray, nasal spray hormone, mucus drainage agents and other symptomatic treatment. 2. Sinusitis: Sinusitis can also cause thick yellow nasal discharge, nasal congestion, headache and other phenomena. Acute phase often apply amoxicillin clavulanate potassium or II generation cephalosporin antibiotics, etc., patients with a history of drug allergy is prohibited. Macrolide antibiotics are often applied in the chronic phase. In addition, saline rinses, nasal spray hormones, and mucus promoters can be applied. Surgery can be performed if necessary. 3. Nasal tumors: nasal tumors can also lead to thick yellow nasal mucus, should be taken to surgical resection of the tumor, and at the same time, pathological examination, to clarify the nature of the tumor. If the tumor is malignant, chemotherapy or radiotherapy is needed to inhibit the spread of cancer cells. There are many reasons for yellowish nasal mucus, after symptoms appear, one should go to the hospital as soon as possible to improve the examination and take standardized treatment according to the doctor’s instruction, and should not ignore the symptoms or use drugs indiscriminately, and the above medicines should be applied under the guidance of the doctor.