Have you ever encountered dry mouth, wanting to drink water, even drinking as much water as possible, dry eyes, even crying without tears, accompanied by some joint pain, dental caries, etc. When these problems occur, what department should you go to for consultation? Here we explain to you the early symptoms of dry syndrome: The gastroenterology department often encounters patients who have dry mouth, dry eyes, dry skin, as well as weakness, abdominal distension and joint pain as their main complaints. After specific examination, he was diagnosed as dry syndrome. Then, what are the early symptoms of dry syndrome? Appearing unexplained dry mouth, dry eyes, disappearance of leucorrhoea, atrophy and dryness of vulva and vaginal mucosa are also common in female patients, and in severe cases, eating dry food, even steamed buns need to take water to send down, and different rashes can appear on the skin, especially erythema nodosum is the most common. In addition, most patients have joint pain at the same time. At this time, you should be alert — dry syndrome (dry syndrome) is around, maybe dry syndrome has come to you quietly. Dry syndrome is a kind of systemic autoimmune disease with dry mouth and eyes as the common manifestation, mainly invading the exocrine glands. It can be seen at any age, but it is more common in women over 40 years old, and only 10% of men develop it. Why are most patients not clearly diagnosed or misdiagnosed at the beginning? The reason is that people lack knowledge about dry syndrome and often go to gastroenterology or liver and skin and endocrinology instead of rheumatology, taking many detours. The etiology and pathogenesis of dry syndrome are still unknown. However, it can be determined that it is related to genetic, immune, sex hormone, viral infection and other factors. Since this syndrome is mostly seen in women, experts speculate that it may be related to immune regulation, because estrogen can enhance immune activity. When dry syndrome occurs, due to a large number of lymphocytes infiltrating exocrine glands such as lacrimal gland, submandibular gland, parotid gland and viscera of human body, the glands are obviously atrophied and the glandular ducts are narrowed. Patients show impaired secretion and various dryness symptoms. For example: eye symptoms of dry cornea, foreign body sensation, eye pain, shyness, redness of eyes, and blurred vision. Oral symptoms dry mouth, thirst, stomatitis, difficulty in chewing, difficulty in pronunciation, inability to eat dry food, damage to teeth; reduced secretion of parotid and sublingual glands. Joint symptoms joint pain, arthritis. Internal secretion glands are invaded respiratory tract, digestive tract, liver, pancreas and kidney, especially the renal tubules are easily invaded. When the sweat glands of the skin are invaded, the patient has little or no sweating. In combination with connective tissue lesions, salivary gland and lacrimal gland function should be measured when the patient presents with the above symptoms, along with increased blood sedimentation, positive rheumatoid factor and hypergammaglobulinemia. The most valuable test is the dry syndrome specific antibody: △mdash; A (also called Ro) anti-nucleoprotein antibody. △mdash (also called La) anti-nucleoprotein antibodies. So experts remind you that once the above symptoms appear, go to the rheumatology department as soon as possible, through effective treatment, patients can mostly be controlled very stable, symptoms disappear, and then consolidate treatment! If it is primary dry syndrome and there is no complication, the prognosis is generally good.