5mm mixed ground glass nodules are usually not serious, can be seen in lung inflammation or benign tumors, and in a few cases are seen in malignant tumors, and require prompt treatment and regular review. Mixed ground-glass nodules are occupational manifestations of the lungs shown on imaging and can be caused by infections and tumors. Viral, bacterial, mycoplasma, and parasitic infections with 5mm mixed ground-glass nodules are usually accompanied by blood changes, and the ground-glass nodules can be reduced or disappeared with the use of antibiotics such as amoxicillin, isoniazid, ribavirin, and other anti-tuberculosis and anti-viral medications as prescribed by the doctor. Tumor-induced 5mm mixed ground-glass nodules should be reviewed regularly. If the nodule grows slowly and has a good morphology, tumor resection or palliative treatment can be performed as prescribed by the doctor. If the growth rate of the nodule is fast or the nodule is splitting, then puncture biopsy should be performed to determine the nature of the tumor, and then tumor resection or radiotherapy should be performed after the doctor’s evaluation. In case of 5mm mixed ground-glass nodules, one should consult a doctor in time, choose the appropriate treatment after examination and evaluation, and undergo regular review to avoid delaying the condition.