If a female patient has a menstrual flow while taking progesterone without finishing the medication, this is an abnormal phenomenon and does not exclude the occurrence of menstrual disorders and endocrine disorders. For patients with heavy bleeding and prolonged bleeding, it is necessary to go to the obstetrics and gynecology department for a blood test for sex hormones and pelvic ultrasound. Under the guidance of a professional obstetrician and gynecologist, adjust the medication according to the condition and stop the use of medication if necessary. Under normal circumstances, during the use of progesterone drugs, menstruation will occur only after 3-5 days of stopping the medication, which is a normal drug reaction and clinically known as withdrawal bleeding.