Chronic rejection after renal transplantation is often characterized by a slow decline in renal function. Symptoms such as water electrolyte metabolic disorder, cardiovascular system manifestations, gastrointestinal discomfort and anemia often appear. 1. Water electrolyte metabolism disorder: Renal tubular secretion of hydrogen ions is impaired or tubular bicarbonate reabsorption capacity is decreased, causing metabolic acidosis. Water and sodium retention, resulting in dilutional hyponatremia, which may be manifested as different degrees of subcutaneous edema and/or body cavity effusion. 2. Cardiovascular system manifestations: with the continuous deterioration of renal function, the prevalence of heart failure increases significantly. Various degrees of hypertension may also occur, mostly due to water and sodium retention, increased renin-angiotensin and/or insufficient production of certain vasodilatory factors. 3. Gastrointestinal symptoms as well as anemia: As renal function continues to decline, gastrointestinal symptoms such as loss of appetite, nausea, and vomiting may also occur. Reduced secretion of erythropoietin by renal tissues can also cause renal anemia. Chronic rejection after kidney transplantation occurs weeks, months or even years after transplantation. If patients experience uncomfortable symptoms, it is recommended to go to the hospital in time to do relevant examinations to clarify the severity of the disease and carry out treatments under the guidance of doctors.