How long a person can live with a blocked blood vessel in the heart is related to the patient’s specific condition. If there are no serious lesions in other blood vessels and they can be actively treated, they can survive for a long time. If there are multiple blood vessels, the condition is more serious, the survival time will be shortened, and there is even a risk of sudden death. There are three main blood vessels in the heart, and if there is an occlusion in one vessel, collateral circulation can be given through the other vessels. If the other blood vessels do not have serious lesions and the patient can be treated actively, some patients can survive for a long time, and a few patients can be treated with coronary artery bypass grafting, and the survival time of the patient is also relatively long. The longer the coronary occlusion, the lower the chance of its opening by intervention, but not without a chance. An experienced interventional center can be consulted or coronary artery bypass graft therapy can be considered. Three-branch lesions are more risky than single-branch lesions. Prolonged occlusion may lead to heart failure, arrhythmias, etc. It is still advisable to evaluate and revascularize as much as possible. It is not possible to assess the survival time of patients with coronary artery disease, and there is inherent uncertainty in the patient’s condition, which may change at any time. Specific treatment needs to follow the doctor’s advice.