Dry and sore throat in the middle of the night may be caused by acute inflammation of the throat, dry air, rhinitis and sinusitis. 1. Acute inflammation of the throat: dry and sore throat in the middle of the night, need to consider the possibility of upper respiratory tract infection. In addition, with gastroesophageal reflux disease, sleep at night in a lying state, due to gastric reflux stimulation of the contents of the local inflammation, there will be symptoms of dry throat. 2. Dry air: In the middle of the night, when the air around the sleeping area is dry, the body will have a dry and sore throat, which is a physiological symptom, not caused by pathological factors. 3. Rhinitis and sinusitis: when suffering from such diseases, due to the blockage of the nose leads to poor ventilation, sleeping will appear open-mouth breathing, mucosal surface secretion will cause evaporation, which leads to a dry and sore throat. The appearance of dry throat in the middle of the night, it is recommended that timely medical treatment, clear causes for targeted treatment.