Hands peeling and itching with small blisters clinically known as blisters, may be caused by ringworm, contact dermatitis, palmoplantar pustulosis and other causes. 1. Ringworm: when the patient’s hand skin is infected with dermatophytes, it may lead to interphalangeal, palm and other parts of the fingers, blisters, flaking, skin roughness and thickening and other symptoms, sometimes causing palm roughness, peeling, cracking and so on. 2. Contact dermatitis: contact dermatitis is an acute inflammatory reaction of the skin, the main clinical manifestations of erythema, mild edema, papules, blisters and even blisters and other lesions, some patients with peeling, itching, swelling and pain and other symptoms. 3. palmoplantar pustulosis: palmoplantar pustulosis is a kind of skin disease characterized by pustules, mostly occurring in the palm of the hand, the palm of the foot and other palmoplantar parts, mainly manifested as erythema, hyperkeratosis, pustules, peeling and other symptoms, the patient appeared to have hand peeling itchy small blisters, may be caused by palmoplantar pustulosis. It is recommended that the patient timely medical examination, actively cooperate with the doctor’s treatment, at the same time, the main hand care, avoid using the hands to contact irritating, allergic substances, such as the emergence of pus, severe pain and other symptoms, should be timely medical treatment.