Keshan disease, also known as endemic cardiomyopathy, is a disease with an unknown cause and was first discovered in Keshan County, Heilongjiang Province in 1935, hence its name. In the past, the mortality rate of Keshan disease was high, but after the founding of New China, the incidence and mortality rate of Keshan disease have been reduced significantly by active prevention and treatment. In 1993, the National Conference on Key Surveillance of Creutzfeldt-Jakob Disease pointed out that there were no new cases of acute, subacute and slow-onset acute attacks, 109 new cases of the potential type were found, with an incidence rate of 4.2 per thousand, and 6 new cases of the slow type were found, with an incidence rate of 0.24 per thousand. Keshan disease should be treated with comprehensive treatment to rescue cardiogenic shock, control heart failure and correct arrhythmias, etc. As far as possible, we should do “three early”, namely early detection, early diagnosis and early treatment. 1, high-dose vitamin c intravenous injection The first dose can be 5-10g, the total amount of 24 hours up to 15-30g. generally can be applied for about a week. Improve myocardial metabolism drugs such as coenzyme a, coenzyme q10, adenosine triphosphate can be used. 2.Hibernation therapy Suitable for frequent vomiting and irritability. After using the drug, because the body’s metabolic rate is reduced, myocardial oxygen consumption is reduced, which is conducive to the recovery of cardiac function. Adults use chlorpromazine 50mg intramuscularly (pediatric dosage 1~2mg/kg), or use chlorpromazine 25mg, promethazine 25mg, pethidine 50mg intramuscularly or intravenously. Frequent vomiting can also be treated with metoclopramide and correction of acid-base balance and electrolyte disturbance. Diazepam can also be used. Pay attention to adequate oxygen supply. 3, the application of vasoactive drugs for hypotension or shock patients with vitamin C and supplemental blood volume after the application of blood pressure still does not rise, you can apply vasoactive drugs such as dopamine, alamine and norepinephrine. If hypotension is accompanied by left heart failure, in addition to cardiac drugs, dobutamine or dobutamine can also be used in combination with sodium nitroprusside, and adjust the drug concentration and drip rate according to blood pressure. 4, cardiac drugs Acute, subacute type with heart failure, it is appropriate to use rapid digitalis preparations such as hairy flower glucoside C 0.4mg or poisonous hairy spinach glucoside k 0.25mg diluted intravenous injection. If the above treatment is not effective, dobutamine, aminopyralidone and metanephrine can be used. In addition, the treatment of acute and chronic heart failure with vasodilators is more effective. In case of pulmonary edema, rapid diuretics such as intravenous tachykinuria or butanuric acid can also be used. 5, anti-arrhythmia frequent ventricular premature beats, ventricular tachycardia can be intravenous or drip lidocaine and magnesium sulfate, to be basically controlled after the following oral drugs can be used to maintain, such as mexiletine, propafenone, amiodarone, propylamine, quinidine, beta-blockers, etc. Supraventricular tachycardia or rapid atrial fibrillation can be maintained with intravenous capsaicin. If the ventricular rate is slow with high or moderate atrioventricular block, adrenocorticotropic hormone, atropine, isoproterenol, etc. can be used for treatment, and artificial cardiac pacing therapy can be placed if necessary. Chronic Creutzfeldt-Jakob disease mainly controls heart failure and arrhythmia, and prevents infection, overwork, cold and other triggers to avoid increasing the burden on the heart. Cardiac-strengthening drugs are generally used to take digoxin orally, 0.125-0.25mg/d for adults, according to the principle of individualization, and adjust the amount as needed. Diuretics are suitable for those who have edema and can be given intermittently or daily orally with dihydrochlorothiazide, ambrisentan and furosemide. Water and electrolyte balance should be paid attention to and corrected at any time. Vasodilators can be used for those who have poor results with the above treatments, especially for intractable heart failure. Isosorbide nitrate, prazosin, hydralazine, phentolamine, captopril, sodium nitroprusside, etc. can be used. In addition, non-digital cardiac agents such as dobutamine, dopamine and amrinone can be used. The treatment of arrhythmia is the same as that of acute Creutzfeldt-Jakob disease. C. Sub-acute type of Creutzfeldt-Jakob disease Treatment principle is the same as that of the slow type, and those with cardiogenic shock are treated as the acute type. Potential Creutzfeldt-Jakob disease Prevent infection, overwork, pay attention to nutrition, and regular follow-up observation.