The main reasons for elevated peripheral vascular resistance are atherosclerosis and thromboembolic disease. 1. Atherosclerosis: peripheral vascular resistance is small vessel resistance, when peripheral small arteries appear atherosclerosis can cause peripheral resistance to rise. Lipid metabolism disorders can cause atherosclerotic lesions, which is characterized by the affected arterial lesions from the intima, generally the first lipid and complex sugar accumulation, hemorrhage and thrombosis, and then the fibrous tissue proliferation and calcium deposits, and there is a gradual metamorphosis of the arterial middle layer and calcification, resulting in the arterial wall thickening and hardening, narrowing of the lumen of the vessel, resulting in an increase in peripheral resistance. 2. Thromboembolic disease: thrombosis and embolism can occur anywhere in the blood circulation in the heart cavity, arteries or veins, the blood in a local coagulation to form a blood clot is called thrombosis; the formation of the thrombus out of the original position, and along the blood flow blockage of other parts of the thrombus is called embolism, resulting in narrowing of peripheral vascular blockade, resulting in peripheral vascular resistance increased. It is recommended to pay attention to develop good living habits to prevent cardiovascular and cerebrovascular diseases, and when discomfort occurs, it is recommended to consult a doctor in time.