In general, venipuncture, which is also known as drawing blood from a vein, is not painful as long as you have the right orders and are well prepared. First of all, it is necessary to be familiar with the patient, talk well with the patient’s family, do a good job of explanation, and strive for the cooperation of the awake patient and be psychologically prepared. In addition, the site can be prepared locally first, prepare the cleaning tray, puncture kit, aseptic operation is definitely necessary to prevent infection. Generally, if bright red blood is drawn, it means that the patient’s artery is mistakenly punctured and should be pulled out immediately, and the puncture site should be compressed for more than five minutes. Only compression is needed, no rubbing back and forth, and repeated punctures should be avoided as much as possible. Generally, venipuncture should be stopped after three unsuccessful punctures. After the puncture, proper pressure is applied to stop the bleeding and prevent the formation of local thrombosis. By doing these points, drawing blood from a vein is actually not painful at all and is very enjoyable.