Congenital “Bigfoot” is a very rare congenital malformation of the lower limbs, the incidence rate is about 1 in 10,000, often found at birth or shortly after birth, the affected toe is thick, can be thickened and become longer with age, when the development of the whole body basically stops after the growth of the giant toe also stops. This disease often leads to ugly feet, walking instability, and due to the inability to find suitable shoes and some nerve compression syndrome, resulting in limb numbness, and even necrosis of the limbs and toes. So, what are the diagnostic tests for congenital “giant feet syndrome”? 1, the face of special: a typical face of acromegaly, hypertrophy of the hands and feet, skull enlargement, thickening of the lips, low tone, jaw protrusion and sparse teeth and other clinical manifestations of acromegaly. Endocrinology and biochemistry examination: plasma GH concentration can be found to be elevated, mostly above 10ng/ml, and there can be PRL elevation, blood glucose elevation, blood phosphorus elevation, thyroid function abnormality and bone metabolism index abnormality and other findings. Oral glucose tolerance test can show hyperglycemia curve, and at the same time can not inhibit the plasma GH level, GH is more than 5ng/ml. TRH excitation test, plasma GH value is more than 50% of the base value of GH, and GH value is more than 10ng/ml. At the same time, SMc and IGF-worker can be obviously elevated. 3, X-ray and CT scanning examination: it can find the enlargement of pterygoid saddle, saddle area occupying lesions, peri-saddle compression, hand and foot enlargement and widening, and X-ray specific manifestations of cranium, long bones and spinal bones, etc., which can assist the diagnosis. 4, special bone examination: such as single-photon or two-photon bone densitometry, and QCT measurement of BMC content, etc., can find osteoporosis and/or osteophytes and other abnormalities, and the QCT measurement value reflects the credibility of the actual bone mineral content, and the CT value is closely correlated with the calcium content of bone, and most of them use the third lumbar vertebrae as the measurement site.